Journal of medical biochemistry
A novel risk prediction model for post-treatment ischemic stroke recurrence using plasma antithrombin III and thromboelastography
By Cheng Y, Huang B and Jiang S.
Abstract
Background
The primary aim of this investigation was to build and test a novel risk prediction model incorporating plasma antithrombin III (ATIII) activity and thrombelastography (TEG)-derived parameters. This approach seeks to enhance the ability to stratify the risk of stroke recurrence among ischemic stroke (IS) patients receiving dual antiplatelet therapy (DAPT).
Methods
In this prospective cohort study, 200 consecutive patients diagnosed with non-cardiogenic IS were recruited during a one-year period (May 2024 to May 2025). All participants had their ATIII activity, TEG parameters, and coagulation function indicators tested within 24-72 hours of DAPT commencement. After initial variable screening via univariate analysis. A logistic regression-based risk model was built, with its ability to distinguish outcomes evaluated using the receiver operating characteristic (ROC) curve.