Diagnostic accuracy of peripheral ultrasound in familial hypercholesterolemia: a systematic review and meta-analysis

Familial hypercholesterolemia is characterized by lifelong exposure to high cholesterol levels and premature atherosclerotic cardiovascular disease. Unequivocal atherosclerosis on imaging reclassifies patients from high to very high risk.

The aim of this systematic review is to evaluate the diagnostic accuracy of carotid ultrasound and femoral ultrasound compared to cardiac computed tomography, for detecting subclinical coronary atherosclerosis in adults with familial hypercholesterolemia with no history or symptoms of atherosclerotic disease.

Studies published in full length in English were identified through a bibliographic database search in eight databases and two trial registers supplemented with backward and forward citation (updated 14 August 2026). Studies were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool and synthesized using a generalized linear mixed model. The protocol was registered on Open Science Framework, osf.io/89z4a.