Observed Metabolic, Hepatic and Renal Changes Alongside Symptomatic Improvement with Amitriptyline, Sertraline and Desvenlafaxine in Adults with Depression: A Comparative Observational Study: doi: 10.7417/CT.2026.2163

Abstract Background: Antidepressants of different classes are broadly comparable in antidepressant efficacy, so the choice between them increasingly rests on their physical health consequences. Head-to-head data comparing a tricyclic antidepressant, a selective serotonin reuptake inhibitor and a serotonin–noradrenaline reuptake inhibitor across a broad panel of metabolic, hepatic, renal, electrolyte and thyroid measures in the same Indian clinical setting remain scarce.