Integrated assessment of Hepatic, Renal, and Vitamin D status in Iraqi patients with Diabetic foot ulcer

Diabetic foot ulcers (DFUs) are one of the most common complications of diabetes mellitus, and DFUs linked to significant morbidity and impaired wound healing. In addition to infection and inflammation, changes in liver and renal function and vitamin D levels could play a role in disease progression and clinical outcome. The purpose of this study was to conduct a comprehensive evaluation of hepatic function, renal function and vitamin D levels among diabetic foot ulcer patients. Materials and Methods: A case–control study was performed using patients with DFUs and apparently healthy controls. Venous blood samples were taken for biochemical analysis. Biochemical liver function tests such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein and serum albumin were performed. The renal function was measured by serum urea, serum creatinine and estimated glomerular filtration rate (eGFR). The serum calcium and 25-hydroxyvitamin D concentrations were also measured. Biochemical parameters were compared among groups by statistical analyses, and statistical significance was considered as P < 0.05.