Annals of Tropical Pathology
Epstein-Barr Virus (LMP-1) and p16 Expression Patterns in Nasopharyngeal Carcinomas subtypes: A 5-year Retrospective Study from Kano, Northern Nigeria
By Aliyu Ahmed Fate, Aminu M. C. Dahiru, Aminu Jika and 1 others.
Abstract
Background
Nasopharyngeal carcinoma (NPC) is one of the most common types of head and neck cancers, characterised by a distinct geographic distribution. The disease has been linked to Epstein-Bar Virus (EBV) infection, and environmental agents. P16 is a cyclin-dependent kinase inhibitor that is involved in cell cycle regulation.
Aim
The aim of this study was to evaluate LMP-1 positivity and p16 overexpression in cases of nasopharyngeal carcinomas (NPC) diagnosed in Aminu Kano Teaching Hospital (AKTH), Kano over a 5-year period between January 1, 2015 and December 31, 2019. Materials and Methods: This was a retrospective study covering five years (2015 to 2019) of all NPC cases diagnosed at the Department of Histopathology, Aminu Kano Teaching Hospital, Kano (AKTH). The collected data included patients’ demographic details, clinical information, histological diagnosis, and p16/LMP-1 immunohisto- chemical status.