Effect of Pregabalin versus Montelukast on TNF-alpha and IL-31 for hemodialysis patients in Iraq (A single center study)

Abstract:- Uremic pruritus severely impacts hemodialysis patients' quality of life. Pregabalin, a GABA derivative, inhibits neurotransmitters, while montelukast blocks leukotriene receptors. This study compares their effectiveness in alleviating this itch and analyzes their distinct impacts on inflammatory markers TNF-alpha and IL-31.

Methods

This prospective- intervention clinical trial. was conducted at the Iraqi Dialysis Center/ Medical City. Patients on hemodialysis therapy for 3 months or more with uremic pruritus randomly divided in to two groups Group P: which included 25 patients treated with pregabalin 50mg, one tablet every other day for 4 weeks Group M: which included 25 patients treated with montelukast 10mg, one tablet every day for 4 weeks Group control: which included 25healthy subject to assess the serum level of TNF-alpha and IL-31. The effectiveness of the medications for each patient in group P&M was evaluated every week over four weeks using the 5-dimension itch scale, a concise questionnaire that may be easily completed its. The 5- dimension scores vary between 5 (indicating no pruritus) and 25 (representing the most severe pruritus) then Pruritus intensity measured using numeric rating scale. The effectiveness of the medications on TNF-alpha and IL-31evaluated by taken blood sample for each patient on group P&M before treatment and after 4 weeks of treatment and compared it with control group.