Estudio comparativo sobre el efecto antidiabético entre cissus quadrangularis y Trigonella foenum-graecum

The increase in the prevalence of diabetes is parallel with an increase in associated risk factors such as being overweight or obese. The revolution of traditional medicine is growing nowadays. Natural products are found to be the better alternative in the current scenario for replacing routine drugs. The aim of this study is to compare the antidiabetic activity of Cissus Quadrangularis and Trigonella Foenum-graecum. The a-amylase inhibition assay was performed using the 3,5-dinitrosalicylic acid (dnsa) method. A sample Cissus Quadrangularis and Trigonella Foenum-graecum extract on five different concentrations were made and a positive control sample was prepared using metformin(500mg) (1 µg/ml) and the reaction was performed similarly to the reaction with plant extract as mentioned above. As the concentration of the sample increased from 20% to 100% microgram/milliliter, there was a noticeable trend of increased inhibition percentage, indicating a dose-dependent response. It was found that fenugreek have better inhibition of a-amylase when compared to pirandai even at the lowest concentration. Although cissus quadrangularis and trigonella foenum-graecum both have antidiabetic characteristics; the evidence indicates that trigonella foenum-graecum is more effective.Received: 12th July 2025.Accepted 1st May 2026.Online publication: 28th September 2026.