American Journal of Pediatric Medicine and Health Sciences
Improving the Laboratory Diagnosis and Differential Diagnosis of Various Forms of Anemia in Oncologic Diseases
By Umirkulova Sitora Ikrom kizi.
Abstract
Objective
to systematize the methods of laboratory diagnosis of the forms of anemia that occur in oncologic diseases and to improve the differential diagnostic algorithm.
Materials and methods
an analytical review was conducted of data presented in international clinical guidelines (ESMO, ASCO/ASH), systematic reviews, and laboratory diagnostic recommendations; the diagnostic value of laboratory parameters (ferritin, transferrin saturation, soluble transferrin receptor, reticulocyte hemoglobin, C-reactive protein, hepcidin, lactate dehydrogenase, haptoglobin, vitamin B12, folic acid, and others) was comparatively assessed.
Results
in oncology patients, anemia is often of mixed origin and may present simultaneously as anemia of inflammation, absolute and functional iron deficiency, chemotherapy-induced myelosuppression, blood loss, bone marrow infiltration, and hemolysis. The traditional ferritin cut-off (