Journal of chemical health risks
Salivary Omics as a Non-Invasive Diagnostic Tool for Oral Cancer: A Systematic Review
By Vikas Kumar.
Abstract
Introduction
Oral squamous cell carcinoma (OSCC) accounts for more than 90% of oral malignancies and is frequently diagnosed at an advanced stage. Because saliva is in continuous contact with the oral mucosa, it accumulates tumour-derived molecules and can be collected non-invasively. The integrated application of genomics, transcriptomics, proteomics, metabolomics and microbiomics — collectively termed salivary omics (salivaomics) — has provided a practical platform for biomarker discovery.
Objectives
To synthesise two decades of evidence (January 2006 to August 2026) on salivary omics approaches for the early detection, prognosis and monitoring of oral cancer, and to evaluate the readiness of these findings for clinical translation.