La Clinica Terapeutica
From Dysbiosis to Malignancy: The Female Genital Tract Microbiome in Endometrial Cancer; Insights from a Systematic Review and Meta-Analysis: doi: 10.7417/CT.2026.2175
By Ahmed Mohamed Fahmy Selim, Mazed Mohamed Ghonemy Ibrahim, Mohamed Selim Mohamed Elbrolosy and 12 others.
Abstract
Background
Emerging evidence suggests that alterations in the female genital tract microbiome may be associated with the development and progression of endometrial cancer (EC). Microbial dysbiosis may contribute to chronic inflammation, immune dysregulation, and metabolic disturbances within the endometrial microenvironment.
Objective
This systematic review and meta-analysis aimed to evaluate alterations in the female genital tract microbiome in women with EC and to identify microbial patterns associated with benign, premalignant, and malignant endometrial conditions.