مجلة جامعة صنعاء للطب والعلوم الصحية
Evaluation of Anti-diabetic Activity of Vonoprazan and its Synergistic Effect with Metformin in Streptozotocin Induced Diabetes in Rats
By Mohammed A. N. Abbas, Mohammed A. Alkhawlani, Hassan Al-Muhibishi and 5 others.
Abstract
Background
Vonoprazan, classified as a potassium-competitive acid blocker, suppresses the secretion of gastric acid and indirectly increases circulating gastrin levels through a feedback mediated mechanism. Recent findings indicate that vonoprazan may influence glucose homeostasis and insulin sensitivity, suggesting a possible role in the modulation of metabolic aberrations, specifically pertaining to the pathophysiology of Type 2 Diabetes Mellitus (T2DM).
Objectives
The current study was conducted to appraise the anti-diabetic properties of vonoprazan and to assess its combined effect with metformin in a rat model of T2DM established via a high-fat diet (HFD) combined with streptozotocin (STZ).
Methods
Twenty-five adult male rats were participants randomly assigned to five experimental groups (n=5): normal control, positive control, diabetic rats administered metformin, diabetic rats administered vonoprazan, and diabetic rats subjected to a dual regimen comprising vonoprazan and metformin. After inducing diabetes, the treatments were delivered via oral gavage once daily for four weeks. At the experimental endpoint, blood samples were processed for biochemical assessment. Pancreatic tissues were excised, weighed, and processed for histological evaluation to investigate morphological alteration.