Zenodo
Metabolomic Alterations in Postmenopausal Women: Experience in a Metropolitan City of South-Eastern Nigeria
By Sylvester Ogbonna Ogbodo, Miriam Obiageli Aniagolu and Onyebuchi Peter Ogbodo.
Abstract
Background
The decline in levels of some hormones during menopause has been associated with metabolic syndromes, particularly cardiovascular diseases, and cardiovascular diseases have been ascribed to hyperlipidemia, insulin resistance and lifestyle changes.
Aim
This study investigated changes in lipid profiles, insulin levels, and body weight in post-menopausal women in Enugu metropolis, an urban town in South-eastern Nigeria.
Method
This was a cross-sectional study and involved 150 post-menopausal women aged 55 to 70 years. One hundred and five (105) pre-menopausal women aged 25 to 40 years were used as controls. Lipid parameters (total cholesterol – TC, high-density lipoprotein – HDL, low-density lipoprotein – LDL, very low-density lipoprotein – VLDL, and triglycerides – TG) and insulin levels were determined spectrophotometrically, while body weights were determined using a digital Weighing Balance.