Journal for Research in Applied Sciences and Biotechnology
Correlation of Serum Alanine Aminotransferase Levels with Hepatic Fibrosis and Steatosis Score Assessed by FibroScan and Controlled Attenuation Parameter (CAP) in Patients with Nonalcoholic Fatty Liver Disease
By Jhumur Ghosh, Nayan Chandra Ghosh and Jaya Ghosh.
Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide, affecting approximately one-third of adults in Bangladesh. Serum alanine aminotransferase (ALT) is routinely used as a biochemical marker of hepatocellular injury; however, its ability to accurately reflect the severity of hepatic steatosis and fibrosis remains uncertain. FibroScan-derived liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) offer noninvasive approaches for assessing hepatic fibrosis and steatosis, respectively, and may provide more direct measures of disease severity.
Objective
This study aimed to determine the correlation between serum ALT levels and hepatic fibrosis and steatosis severity measured by FibroScan and CAP in patients with NAFLD.