Zenodo
Vitamin D, vitamin B12 and thyroid function recorded at the first headache-coded visit and later acute analgesic prescribing: a routine-records cohort study
By Özgün Rüzgar Çatal, Selen Gür-Özmen, Uygar Çatal and 3 others.
Abstract
Background
Vitamin D, vitamin B12 and thyroid results are often available at a first headache visit, but their relation to later acute treatment is unclear, and testing is selective. We estimated whether 25-hydroxyvitamin D [25(OH)D], vitamin B12, thyroid-stimulating hormone (TSH) and free thyroxine (T4) recorded at the first headache visit were associated with acute analgesic prescribing from that day onward.
Methods
Retrospective electronic health record cohort of 10,898 adults with a new headache code (G43, G44, R51) at a secondary-care neurology clinic in Türkiye, 2023–2024, with linked laboratory results. As results were carried forward, the exposure was the most recent value recorded at the first visit. The outcome was ≥2 acute analgesic prescription items. Odds ratios (OR) per standard deviation (SD) were estimated with inverse probability-of-measurement weighting, with complete-case and imputed analyses; the equivalence margin was 0.80–1.25.