In a patient with psychotic depression, will the addition of antipsychotics improve the outcome?

22 October 2026Original research1 min read

By Tripdatabase.

Abstract

Evidence shows that adding antipsychotics to treatment for psychotic depression can improve clinical outcomes compared to antidepressant monotherapy or placebo. Monitoring and managing potential side effects is important for optimizing treatment efficacy and patient safety.

Keywords

Treatment of Major Depression
psychotic depression
antipsychotic augmentation

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antidepressant monotherapy

treatment outcomes

antipsychotic adverse effects

patient safety

treatment efficacy

Open access

Authors

Tripdatabase

Source

Published in Zenodo (CERN European Organization for Nuclear Research). The abstract is shown as published and remains the work of its authors; read the full article at the source.

doi.org/10.5281/zenodo.23554812

Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.

At a glance

Journal: Zenodo
Type: Original research
Published: 22 October 2026
Specialty: Psychiatry
Read time: 1 min
Authors: 1
DOI: 10.5281/zenodo.23554812