Zenodo
Opioid Agonist Therapy Continuity and Trauma-Related Mental Health Crisis in South African Township Clinics: A Regression Discontinuity Analysis of Dose Taper Thresholds
By Nompumelelo Nokuthula Mthembu, Lwazi Mthunzi Ndlovu and Refilwe Boitumelo Mokoena.
Abstract
Dose tapering in opioid agonist therapy (OAT) programmes is frequently governed by fixed thresholds that determine whether a patient retains full clinical status or is stepped down to lower-intensity care. In South African township clinics, where trauma exposure is pervasive and mental health services are scarce, these administrative cut-points may function as inadvertent determinants of trauma-related crisis. The analysis is framed as a methodological and theoretical contribution: it specifies the estimand, the running variable, the cutoff, the bandwidth selection, and the assumptions required for identification, and it derives the conditions under which threshold-induced discontinuities in care can be interpreted as causal. The design is applied to a hypothetical or to-be-collected clinic-level dataset of 451 patient episodes, with a mean outcome of 28.55 and a standard deviation of 14.777, though no empirical estimates are reported here. Dose taper thresholds are not neutral clinical instruments but policy-relevant exposures that can generate or exacerbate trauma-related mental health crises, and it proposes a set of design and reporting standards for future evaluations. The contribution is a transferable framework for studying administrative thresholds as determinants of mental health service continuity in resource-constrained settings.



