Zenodo
Inflammatory signature of subcutaneous fat after weight loss and regain in women undergoing repeated bariatric surgery
By Ariel Shneyour, Assaf Rudich, Yulia Haim and 13 others.
Abstract
Context
Repeated metabolic-bariatric surgery (MBS, r-BS) represents 10–25% of all MBS and is commonly-performed for weight regain after prior significant weight-loss. It remains unclear how adipose tissue adapts to surgically-induced weight-loss-regain in obesity.
Objective
We hypothesized that compared to primary bariatric surgery (p-BS), women undergoing r-BS exhibit a distinct adipose tissue signature.
Design
Subcutaneous/visceral adipose tissues (SAT/VAT, respectively) from female MBS patients were assessed histologically/molecularly/functionally (activation of human microglia cells by SAT-secretome).
Setting
Elective MBS in a public university hospital.