Features of early detection and multidisciplinary rehabilitation of POST-COVID-19 complications

Aim. To systematically evaluate early detection modalities and multidisciplinary rehabilitation strategies in patients with post-acute sequelae of COVID-19 (Long COVID / post-COVID condition). Methodology. A prospective-retrospective clinical cohort study of 184 patients (aged 18–68 years) recovering from moderate-to-severe SARS-CoV-2 infection was conducted between 2022 and 2025 at the Andijan State Medical Institute Clinic and Simulation Centre. Clinical, functional, laboratory, and radiological parameters were monitored, including High-Resolution Computed Tomography (HRCT), spirometry, DLCO (diffusing capacity of the lung for carbon monoxide), 6-Minute Walk Test (6MWT), D-dimer, hs-CRP, cardiac troponin I, Post-COVID-19 Functional Status (PCFS) scale, Fatigue Severity Scale (FSS), and Montreal Cognitive Assessment (MoCA). Results. Baseline screening demonstrated persistent pulmonary diffusion impairment (DLCO < 80% predicted) in 68.5% of patients, microvascular/thrombotic risks (elevated D-dimer and hs-CRP) in 42.4%, and neurological/cognitive sequelae ("brain fog", severe post-viral fatigue) in 54.3%. Patients participating in an early structured multidisciplinary rehabilitation program (initiated within 30 days post-acute recovery; Group 1, n=92) exhibited a 34.8% accelerated functional recovery rate compared to delayed/standard care (Group 2, n=92). Early heart-rate guided pacing significantly reduced Post-Exertional Malaise (PEM) relapse rates (p < 0.001). Conclusion. Early diagnostic screening combined with a staged, multidisciplinary rehabilitation protocol significantly mitigates long-term disability, restores cardiorespiratory tolerance, and enhances quality of life in post-COVID patients.