Physicochemical Stability and Pharmaceutical Compatibility of Ciprofol with Five Adjuvant Drugs for Gastrointestinal Endoscopy: An In Vitro Evaluation

Background/Objectives: Ciprofol is a novel GABAₐ-receptor agonist sedative widely used for gastrointestinal endoscopic sedation–anesthesia due to its rapid onset, fast recovery and favorable cardiovascular tolerance. Intravenous anesthetic drug administration via Y-site co-infusion is a common clinical practice during endoscopic procedures, yet systematic physicochemical compatibility data for ciprofol with adjuvant injectable agents remain limited.

Methods

In this in vitro study performed under static laboratory conditions, ciprofol injection was mixed 1:1 (v/v) with lidocaine, nicardipine, norepinephrine, cisatracurium besilate and atropine at clinical concentrations and stored at (25 ± 1) °C. Multiple physicochemical indicators, including macroscopic–microscopic morphology, pH, zeta potential, droplet size and polydispersity index (PDI), osmolality, and residual drug content, were evaluated at 0, 2, 4, 6 and 8 h.