Pediatric Reports
Characterizing the Novel CRP, IP-10, and TRAIL Host-Response Protein Signature in Pediatric Kingella kingae Infections—A Retrospective Cohort Study
By Vered Nir, Dima Mreisat, Vered Schichter Konfino and 4 others.
Abstract
Background
Kingella kingae is a primary cause of pediatric osteoarticular infections. Diagnosis is challenging due to mild clinical presentations and fastidious culture growth, often mimicking viral illnesses. The MeMed BV™ assay measures C-reactive protein (CRP), interferon gamma-induced protein 10 (IP-10), and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) to differentiate bacterial from viral infections, but its utility in K. kingae has not been evaluated.
Objectives
To characterize the CRP, IP-10, and TRAIL profiles in pediatric patients with confirmed K. kingae infections compared to viral and classical bacterial cohorts.