Nutrients
Association Between Serum Folate Concentrations and Dyslipidemia Among Children and Adolescents in Zhejiang Province, China: A Cross-Sectional Study
By Chen Liu, Yi Wang, Lichun Huang and 7 others.
Abstract
Background
Dyslipidemia can emerge during childhood and persist into adulthood. Although folate is involved in pathways relevant to lipid metabolism, its association with lipid abnormalities in children and adolescents remains unclear. We examined the associations of serum folate concentrations with lipid parameters and dyslipidemia subtypes in this population.
Methods
This cross-sectional study included 1379 participants aged 6–17 years from the 2024 Zhejiang Provincial Nutrition and Health Surveillance Program, China. Serum folate was measured by liquid chromatography–tandem mass spectrometry. Associations with seven lipid parameters and four dyslipidemia subtypes were evaluated using multivariable regression, with additional restricted cubic spline, subgroup, and sensitivity analyses.