Efficacy and Safety of Cuban Policosanol on Cognitive Function and Antioxidant Status in Adults with Subjective Memory Decline: A 12-Week Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial

Objectives

Early non-pharmacological interventions for people with subjective memory decline (SMD) are increasingly advocated in preventing age-related cognitive decline and potentially delaying progression to mild cognitive impairment or dementia. In this multicenter clinical trial (RAYDELP1), we evaluated the efficacy and safety of sugarcane-derived Cuban policosanol (PCO) on cognitive function, superoxide dismutase (SOD) activity, inflammatory markers, and metabolic panels in adults aged 55–85 years with subjective cognitive complaints.