Nutrients
The Effect of Fibre-Rich Gluten Free Products on Glycaemic Regulation, Gut Symptoms, and Targeted Gut Microbial Taxa in Women with Coeliac Disease: A Randomised Controlled Trial
By Solveig Ivara Watters, Mari C. W. Myhrstad, Elisabeth Austad and 9 others.
Abstract
Background
The only treatment for coeliac disease (CeD) is a gluten-free diet. Gluten-containing cereals constitute a major source of dietary fibre, raising concerns about fibre intake for individuals with CeD.
Objective
The present study aimed to investigate the effect of pseudocereal-based, fibre-rich gluten-free products on glycaemic regulation in women with CeD. Secondary endpoints were changes in gut symptoms, targeted gut microbial taxa, and inflammatory and metabolic markers.
Methods
This double-blind, randomised, controlled trial was conducted remotely and included 30 women with CeD. Participants were allocated to consume either pseudocereal-based, fibre-rich gluten-free products (experimental) or benchmark products (control) for three weeks. Before and after the interventions, participants underwent an oral glucose tolerance test (OGTT), reported gastrointestinal symptoms, and provided blood samples to analyse micronutrients, metabolic markers, and a satiety hormone, and faecal samples for targeted gut microbial taxa analyses.