Triglyceride-Glucose Index and Systemic Inflammatory Markers in Polyendocrine Metabolic Ovarian Syndrome (Polycystic Ovary Syndrome): A Cross-Sectional Study

Background/Objectives: Low-grade chronic inflammation is recognized as part of the systemic profile of polyendocrine metabolic ovarian syndrome (PMOS, formerly polycystic ovary syndrome, PCOS), although whether this inflammatory signal tracks insulin resistance, adiposity, or both remains unclear. This study evaluated whether the triglyceride-glucose (TyG) index, a surrogate of insulin resistance, is associated with subclinical inflammation independently of body mass index (BMI) in women with PMOS.

Methods

In this retrospective cross-sectional study of 150 women with PMOS, the TyG index was calculated from fasting triglycerides and glucose. C-reactive protein (CRP; standard assay) and the systemic immune–inflammation index (SII) were pre-specified primary markers; the neutrophil-, platelet-, and monocyte-to-lymphocyte ratios (NLR, PLR, and MLR) and the systemic inflammation response index (SIRI) were secondary. Associations were assessed using Spearman correlation and multivariable linear regression adjusted for age and BMI, with component, extended-adjustment, tertile, and BMI-interaction analyses.