Life
Severe Obstructive Sleep Apnea Is Associated with Cholesterol Target Non-Attainment in Patients Undergoing Cardiac Surgery: A Secondary Analysis of a Prospective Observational Cohort
By Andrei Raul Manzur, Gabriela Mara, Ana Lascu and 7 others.
Abstract
Background
Obstructive sleep apnea (OSA) has been associated with adverse cardiometabolic profiles, but its relationship with cholesterol target attainment in patients receiving lipid-lowering therapy remains incompletely characterized. We investigated the association between severe OSA and non-attainment of predefined cholesterol thresholds in patients undergoing elective cardiac surgery.
Methods
This secondary analysis included 142 adults from a prospectively assembled observational cohort. Participants underwent in-hospital preoperative Type III cardiorespiratory polygraphy, fasting lipid assessment, and documentation of lipid-lowering therapy. Severe OSA was defined as an apnea–hypopnea index ≥30 events/h. The primary outcome was non-high-density lipoprotein cholesterol (non-HDL-C) ≥ 100 mg/dL. Multivariable models were adjusted for age, sex, body mass index, diabetes mellitus, high-intensity statin therapy, and non-statin lipid-lowering therapy.