Journal of Personalized Medicine
Collagen-Stratified Abdominal Wall Closure Combined with Subaponeurotic Platelet-Rich Plasma: Feasibility and Early Incidence of Postoperative Ventral Hernia in a Prospective, Uncontrolled Single-Centre Cohort
By K Moshkal, S. Khaidarov, Nurlan Jainakbayev and 5 others.
Abstract
Background
Fascial healing depends on type I collagen, yet collagen metabolism is rarely considered when choosing an abdominal wall closure technique.
Objective
to describe the early incidence of postoperative ventral hernia (PVH) after closure stratified by preoperative collagen biomarkers and combined with subaponeurotic platelet-rich plasma (PRP).
Methods
Prospective single-centre cohort of 106 consecutive adults (October 2024–December 2025) undergoing elective hernia repair (n = 61) or other abdominal surgery (n = 45). Serum P1NP and CTX-I defined low (n = 35), moderate (n = 27) and high (n = 44) collagen groups. Mesh was used in all low-collagen patients, in 12 moderate-collagen patients and in no high-collagen patients; all patients received PRP. Incidence was reported with Wilson 95% confidence intervals (CIs); groups were compared with exact tests, Welch’s ANOVA and multinomial regression.