Journal of Clinical Medicine
Fluoroquinolone Exposure and Other Factors Associated with Achilles Tendon Rupture: A Nationwide Nested Case–Control Study
By Jae-Yong Park, Hye Chang Rhim, Young-Min Kwon and 4 others.
Abstract
Background/Objectives: Fluoroquinolones have been associated with tendon disorders, including Achilles tendon rupture (ATR). We investigated the associations of individual fluoroquinolone prescriptions and patient characteristics with ATR in a nationwide Korean claims dataset.
Methods
This nested case–control study used Korean National Health Insurance Service data from 2009 to 2019. We included 40,240 ATR cases identified by KCD code S86.0 and 160,960 risk-set-sampled controls. Exposure was defined as a fluoroquinolone prescription lasting more than six days within 180 days before the index date. Poisson regression described population rates; unconditional multivariable logistic regression estimated adjusted odds ratios (aORs).