Journal of Clinical Medicine
Splenic Enlargement During Neoadjuvant Chemotherapy for Gastric Cancer: Treatment-Related Phenomenon or Prognostic Biomarker?
By Ezgi Altınsoy, Veysel Cem Özcan, Abdurrahman Başpınar and 4 others.
Abstract
Introduction
Spleen volume (SV) may increase during systemic chemotherapy, potentially reflecting treatment-related hepatic, hematological, and immune alterations. However, the clinical significance of SV changes during neoadjuvant chemotherapy (NAC) for gastric cancer remains unclear. This study evaluated SV changes during NAC and their associations with radiological response and overall survival (OS).
Methods
This retrospective cohort study included 111 patients with gastric adenocarcinoma who received NAC followed by curative-intent gastrectomy. SV was measured on computed tomography before and after NAC using semiautomated volumetric segmentation. Relative SV change (ΔSV%) was calculated. Radiological response was assessed according to RECIST 1.1. Associations of ΔSV% with objective response and OS were evaluated using logistic and Cox regression analyses, respectively.