Journal of Clinical Medicine
Prevalence of Triglyceride–Glucose Index-Defined Insulin Resistance and Its Association with Recorded Cardiovascular Disease Among Adults in the Municipality of Naples: A Cross-Sectional Primary-Care Study
By Sergio Fazio, Vincenzo Santagada, Gaetano Piccinocchi and 7 others.
Abstract
Objectives
Assess the prevalence of insulin resistance (IR) in the adult population of the municipality of Naples in Italy and its association with cardiovascular diseases.
Methods
We performed a cross-sectional analysis of adults aged 18–60 years without recorded diabetes who were followed by general practitioners affiliated with the COMEGEN cooperative, ASL Napoli 1 Centro. Participants were included if concurrent fasting glucose and triglyceride values from the preceding six months were available to calculate the triglyceride–glucose index (TyG), as a surrogate index of IR. IR was defined using an operational cut-off of TyG ≥ 8.5.
Results
Of 17,510 selected records, 17,481 had calculable TyG; 5707 met the IR criterion (32.65%; 95% CI 31.96–33.35%). Recorded cardiovascular conditions were present in 44.98% with IR and 28.90% without IR. The adjusted odds ratio (OR) for IR was 1.252 (95% CI 1.137–1.379; n = 9866), and the adjusted prevalence ratio (PR) was 1.133 (95% CI 1.079–1.190). Adding IR to a model containing age, sex, and BMI increased the ROC AUC from 0.7438 to 0.7452 (p = 0.0477), a negligible absolute gain.