Journal of Clinical Medicine
Association Between Admission Estimated Glomerular Filtration Rate and Long-Term Mortality in Patients with Acute Myocardial Infarction
By Guy Vishnevsky, Ammie Wolf, Yoav Perez and 5 others.
Abstract
Background
Reduced estimated glomerular filtration rate (eGFR) and acute kidney injury (AKI) are common in patients with ST-segment elevation myocardial infarction (STEMI) and adversely influence prognosis. This retrospective cohort study evaluated the association between admission eGFR and one-year mortality following STEMI, accounting for admission AKI and cardiovascular risk factors.
Methods
Consecutive adults (n = 2903) admitted with STEMI undergoing primary percutaneous coronary intervention (PCI) at a tertiary center were analyzed, selected from 2949 initially screened patients after excluding those treated conservatively or with thrombolysis (n = 14), those with a final discharge diagnosis other than STEMI (n = 21), and early deaths within 24 h of presentation (n = 11). Admission eGFR was calculated using the 2021 CKD-EPI creatinine equation and categorized into quintiles. The primary outcome was all-cause one-year mortality, assessed using multivariable logistic regression and secondary Kaplan–Meier survival analysis.