Coffee Consumption, Serum Copeptin, and Selected Echocardiographic Parameters in Patients with ADPKD: A Cross-Sectional Study

Background/Objectives: Coffee consumption has been suggested to influence arginine vasopressin-related pathways and cardiovascular function. However, its relationships with serum copeptin and cardiac parameters in patients with autosomal dominant polycystic kidney disease (ADPKD) remain unclear. This study aimed to investigate the association between habitual coffee consumption and serum copeptin concentrations and selected echocardiographic parameters in patients with ADPKD.

Methods

In this cross-sectional study, 73 patients with ADPKD were classified as coffee consumers (n = 35) or non-consumers (n = 38). Serum copeptin measurements were available for 62 patients. Coffee consumption was assessed using a standardized questionnaire and expressed as grams of dry coffee per month. Multivariable models were used to assess associations with log-transformed copeptin, mitral annular e′ velocity, and E/e′ ratio.