Journal of Clinical Medicine
Exploratory Risk Assessment of Cardiovascular Diseases Using Antiphospholipid Antibody-Related Scores in Patients with ANCA-Associated Vasculitis
By Oh Chan Kwon, Yong-Beom Park and Sang‐Won Lee.
Abstract
Background
Antiphospholipid antibodies have been found in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This study aimed to evaluate the accuracy of the global antiphospholipid syndrome score (GAPSS) derivatives in predicting cardiovascular diseases in Korean patients with AAV, and to derive a simple candidate index for cardiovascular diseases.
Methods
This was a retrospective cohort study including 170 patients with AAV. The adjusted GAPSS (aGAPSS), aGAPSS specific for cardiovascular diseases (aGAPSScvd), and aGAPSS for Korean patients with APS (aGAPSS [KAPS]) were calculated in each patient. The cardiovascular diseases were defined as cerebrovascular accident (CVA) or acute coronary syndrome (ACS). The accuracy of each index was assessed by estimating the area under the curve (AUC). An exploratory multivariable Cox proportional hazards model with a backward elimination method was performed to derive a candidate index. Covariates consisting the aGAPSScvd were included in the model.