Journal of Clinical Medicine
Prognostic Implication of a CT-FFR-Based Functional SYNTAX Score in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention
By Qiaoyu Shao, Uwe Joseph Schoepf, Xiaoteng Ma and 4 others.
Abstract
Background
This study aims to investigate the value of a SYNTAX score (SS) based on coronary computed tomographic angiography (cCTA)-derived fractional flow reserve (CT-FFR), termed “Functional SYNTAX score” (FSSCTA), to predict major adverse cardiovascular events (MACEs) in patients undergoing percutaneous coronary intervention (PCI).
Methods
This cohort study included 876 patients who underwent cCTA and underwent PCI within 30 days during 2016–2020. CT-FFR was calculated by a machine learning algorithm. All 876 patients were divided into a low-risk group (≤22) and an intermediate-to-high-risk group (>22) with cCTA-based SS (SSCTA) as the control.
Results
Based on the FSSCTA, 10.4% (91/876) of patients were reclassified to the low-risk group, and 2.9% (25/876) of patients were reclassified to the intermediate-to-high-risk group. MACEs occurred in 16.6% (145/876) of patients over a median follow-up period of 19.4 months. FSSCTA and invasive coronary angiography-based SS (SSICA) were independently associated with the risk of MACEs regardless of whether they were in continuous or categorical form (FSSCTA: c continuous HR 1.082, 95% CI 1.038–1.128; categorical HR 1.865, 95% CI 1.138–2.305.