Journal of Clinical Medicine
Real-World Management and Outcomes of Probable and Indeterminate UIP Patterns on HRCT: A Retrospective Cohort Study and Implications for the 2022 IPF Guideline
By Gülce Cansu Serin, Ebru Dumlupınar, Çağlar Uzun and 1 others.
Abstract
Background
The 2018 ATS/ERS/JRS/ALAT guideline conditionally recommended surgical lung biopsy (SLB) for patients with probable or indeterminate usual interstitial pneumonia (UIP) patterns on high-resolution computed tomography (HRCT). This study assessed the real-world use of this recommendation and outcomes of patients with probable or indeterminate UIP.
Methods
HRCT scans of 1255 patients with interstitial lung disease (ILD) followed between 2012–2021 were retrospectively reviewed. A total of 185 patients met the inclusion criteria. We re-evaluated the HRCT scans and classified them through multidisciplinary discussion (MDD) involving one thoracic radiologist, one pulmonary pathologist, one rheumatologist, and at least three pulmonologists specializing in ILD. We analyzed clinical features, biopsy rates, final diagnoses, and survival outcomes.