Journal of Clinical Medicine
Longitudinal Voice Outcomes After Atelocollagen Injection Laryngoplasty for Vocal Fold Paralysis and Vocal Fold Atrophy/Sulcus
By Kiyohito Hosokawa, Masayuki Nozawa, Takanari Kawabe and 11 others.
Abstract
Background
Atelocollagen injection laryngoplasty is a minimally invasive treatment for glottic insufficiency, but the durability of its effects and whether longitudinal responses differ according to the underlying disorder remain unclear.
Methods
We retrospectively analyzed prospectively collected clinical data from three institutions. The cohort comprised 92 patients and 142 injection episodes, including 75 patients with vocal fold paralysis and 17 with vocal fold atrophy/sulcus. Acoustic Voice Quality Index (AVQI), maximum phonation time (MPT), and Voice Handicap Index-10 (VHI-10) were evaluated from baseline through 1 year. Longitudinal changes were analyzed using mixed-effects models, and clinically meaningful response was assessed using prespecified criteria. Extended follow-up at 1.5 years and ≥2 years was evaluated in the subset of patients with vocal fold paralysis with available long-term data.