Journal of Clinical Medicine
Residual Sleep-Related Respiratory Events During Early Versus Long-Term NIV Follow-Up: Burden and Relationship with Gas Exchange
By Pierre Tankéré, Marjolaine Georges, Ameline Vagner and 5 others.
Abstract
Background
A recent study published by our group demonstrated that patient–ventilator asynchrony (PVA) is independently associated with impaired gas exchange during long-term non-invasive ventilation (NIV). We aimed to determine whether the burden and phenotype of residual PVA vary according to disease category, NIV initiation context and follow-up timing, and whether the relationship between PVA and gas exchange differs according to follow-up timing.
Methods
We performed a secondary analysis of 123 NIV-treated patients included in the primary study. PVA burden, upper-airway obstructive events and leaks were compared across disease categories and follow-up settings. Multivariable models for gas exchange outcomes were extended by introducing interaction terms between PVA burden and follow-up category. Patients underwent either long-term follow-up performed >3 months after NIV initiation (n = 74), early acute follow-up, i.e., after stabilization following NIV initiation in acute respiratory failure (n = 30), or early planned follow-up, i.e., within 3 months after NIV initiation in stable chronic respiratory failure (CRF) (n = 19).