Journal of Cardiovascular Development and Disease
Invasive Complications and Infection-Related Reconstruction in Bicuspid Versus Tricuspid Native Aortic Valve Endocarditis: A 12-Year Surgical Cohort Study
By Yuanhang Zhai, Lanlin Zhang, Shuofang Ren and 5 others.
Abstract
Background
Detailed operative evidence comparing invasive anatomy and reconstruction between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) cases of native-valve infective endocarditis is limited. We examined the association of BAV morphology with non-leaflet invasive complications and infection-related reconstruction.
Methods
We retrospectively studied 317 adults who underwent surgery for native aortic valve infective endocarditis from 2013 through 2025 (113 BAV; 204 TAV). The primary outcome was any non-leaflet invasive complication; infection-related reconstruction was a secondary operative outcome reflecting operative management of invasive anatomy. Modified Poisson regression estimated adjusted prevalence ratios (aPRs), corresponding 95% confidence intervals (CIs), and marginally standardized absolute differences. Site-specific and invasive-subgroup analyses were exploratory.