International Journal of Molecular Sciences
Salivary Melatonin Levels in Comparison with Disease Features and Antihistamine Use: Prospective Follow-Up of Atopic Dermatitis Patients
By Renata Tomašević, Milena Hanžek, Tamara Sušić and 3 others.
Abstract
Background
Atopic dermatitis (AD) is a common inflammatory dermatosis often accompanied by itching and sleep disturbances. Various treatment options exist, including antihistamines (AHs), even though current clinical recommendations do not mention them.
Methods
This prospective exploratory study measured and recorded salivary melatonin at two timepoints (T1 and T2) in three groups of participants: those not treated with AHs, those who discontinued H1-AHs, and those for whom H1-AHs were introduced. Also assessed were disease severity (Scoring Atopic Dermatitis/SCORAD and Eczema Area and Severity Index/EASI), pruritus severity (Peak Pruritus Numeric Rating Scale/NRS), and sleep quality (Pittsburgh Sleep Quality Index/PSQI).