Age-Driven Cardiovascular Risk Scores Differ Across Antiretroviral Regimens Among People Living with HIV in the Colombian Caribbean Region

Background/Objectives: People living with HIV (PLHIV) face an elevated burden of cardiovascular disease, and general-population and HIV-specific risk scores are commonly used for stratification, though data from Latin America, particularly Colombia’s Caribbean region, remain scarce. This study aimed to determine the distribution of cardiovascular risk, assessed through the Framingham, ASCVD ACC/AHA, and D:A:D scores, and to compare these scores across antiretroviral therapy (ART) regimens among PLHIV individuals in the Colombian Caribbean region.

Methods

This cross-sectional study included 147 adult PLHIV patients receiving ART at care sites across the Colombian Caribbean. Sociodemographic, clinical, immunovirological, and treatment-related variables were compared across cardiovascular risk categories (low, moderate, high) using the Kruskal–Wallis test for continuous variables and Chi-squared or Fisher’s exact tests for categorical variables, as appropriate to expected cell counts. Agreement between the three scores was assessed with weighted Cohen’s kappa. Factors independently associated with high cardiovascular risk were evaluated using Bayesian multivariate logistic regression (full and parsimonious models).