Cosmetics
Topical Insulin in Atrophic Acne Scarring: A Systematic Review of Efficacy, Safety, and Patient Satisfaction
By Ahmed A. Yusuf Alaysereen, Abdullah Hussain, Bushra Hasan and 5 others.
Abstract
Background
Atrophic acne scars are challenging to treat and have a negative psychological impact. Insulin has been tried as a topical adjuvant and stimulates fibroblast activity, collagen deposition, and keratinocyte migration.
Objectives
To evaluate topical insulin for atrophic acne scars in terms of its effectiveness, safety, and patient-rated results.
Methods
Five databases were searched for research on topical insulin, either alone or in conjunction with a procedure, without regard to the date. Records were screened, extracted, and evaluated in duplicate (RoB 2 or ROBINS-I) each by two independent researchers, using Covidence.