Clinics and Practice
Inflammatory and Metabolic Biomarkers Associated with Chronic Subdural Hematoma Recurrence: A Single-Center Retrospective Cohort Study
By Bilal Ertuğrul and Harun Kömürcü.
Abstract
Background
Chronic subdural hematoma (CSDH) recurs in 5–20% of patients despite surgical treatment, and readily accessible biomarkers associated with recurrence remain limited. This study evaluated perioperative hematological, biochemical, and metabolic biomarkers associated with CSDH recurrence, focusing on preoperative lactate and the lactate-to-albumin ratio (LAR).
Methods
This retrospective single-center cohort study included 163 adults who underwent burr-hole evacuation for CSDH between January 2021 and December 2025. All patients underwent saline irrigation without placement of a postoperative subdural drain, in accordance with the institutional surgical protocol. Clinical, radiological, laboratory, and perioperative arterial blood gas data were analyzed. Recurrence was defined as symptomatic re-expansion requiring repeat surgery within six months. Receiver operating characteristic (ROC) analysis and multivariable logistic regression were used to assess discrimination and associations with recurrence.