Current Issues in Molecular Biology
The Construction and Validation of a Machine Learning Model for Major Depressive Disorder Based on Astrocytes and Mitochondrial Dynamics
By Shi Lin, Gaoyuan Wang, Xiaoqin Shao and 8 others.
Abstract
Background
Astrocytes play an important role in depression. However, their specific mechanisms, especially their subcellular mechanisms, remain unclear.
Objective
We aimed to identify key genes associated with mitochondrial dynamics and astrocytes in Major Depressive Disorder (MDD), construct a diagnostic prediction model, and elucidate their regulatory mechanisms in neuroinflammation.