Current Issues in Molecular Biology
Laminin-Derived Peptides and Isoforms: A Multifaceted Review of Their Roles in Cancer, Neurodegeneration, Inflammation, Tissue Regeneration, and Exercise Physiology
By Elcirley Luz Silva, Gilberto Kocerginsky, Cláudia Marlise Balbinotti Andrade and 3 others.
Abstract
Background
Laminins are heterotrimeric basement membrane glycoproteins whose chain composition, molecular processing, receptor engagement, and cellular source determine their biological effects.
Methods
We conducted an integrative narrative search of PubMed and manually screened reference lists for studies of laminin isoforms, laminin-derived peptides, and polylaminin in cancer, neurological disorders, inflammation, tissue regeneration, wound healing, and exercise-related adaptation.
Results
The evidence is heterogeneous and is predominantly mechanistic, in vitro, or preclinical. Laminin isoforms and derived peptides can produce opposing effects depending on the isoform or sequence, receptor, presentation format, tissue context, disease stage, and experimental model. Polylaminin is an experimental biomaterial with encouraging but preparation-dependent preclinical activity in selected neural repair models and in vitro stem cell culture.