Cancers
Decade-Stratified Malignancy Risk in Hysteroscopic Polypectomy: A Multicenter Registry Analysis of 9269 Procedures
By Rina Tamir Yaniv, Tamar Tzur, Hila Goldstein and 2 others.
Abstract
Background
Malignancy risk in hysteroscopic polypectomy specimens rises with age and postmenopausal status, but decade-stratified absolute rates from large, unselected cohorts remain scarce, limiting the quantitative basis for pre-procedural risk counseling.
Objective
To estimate decade-specific absolute malignancy rates and to determine how the documented procedural indication modifies that risk.
Methods
Retrospective multicenter cohort study with SNOMED-coded histology. All hysteroscopic polypectomies at five Assuta Medical Center sites from January 2019 to April 2026 with a linked histology result constituted the analytic cohort (n = 9269; 75.1% of a base cohort of 12,339). The primary outcome was histologically confirmed endometrial malignancy, defined by SNOMED morphology and topography coding. Multivariable logistic regression adjusted for weight category, hospital site, and calendar year.