Biomolecules
Cannabidiol Alleviates Aβ1–42-Induced Cognitive Deficits and Neuronal Injury Associated with Modulation of the AEA–FAAH–CB1R Axis and BDNF/TrkB Signaling
By Yan Kong, Juan Peng, Jian Sun and 1 others.
Abstract
Background
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuronal injury. Cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa L., has neuroprotective potential, but its underlying mechanisms remain unclear.
Purpose
This study investigated the effects of CBD on Aβ1–42-induced cognitive impairment and hippocampal injury, focusing on endocannabinoid and BDNF/TrkB signaling.