International Journal of Nanomedicine
Development of Triamcinolone Acetonide-Loaded Nanoparticles for Inflammatory Knee Arthritis Treatment
By Shu‐Jyuan Yang, Tzu-Hao Tseng, Po-Ju Ting and 3 others.
Abstract
Introduction
Intra-articular corticosteroid injections (IACIs) provide an alternative treatment for inflammatory arthritis. Nevertheless, IACIs are limited by adverse effects, including injection-related pain, corticosteroid-induced chondrocyte toxicity, and progressive cartilage degeneration following prolonged use.
Methods
In this study, human serum albumin (HSA) was employed as a biocompatible nanocarrier for the encapsulation of triamcinolone acetonide (TA) to develop TA/HSA nanoparticles (TA/HSA NPs). The physicochemical characteristics and drug-release profile of the TA/HSA NPs were characterized. The in vitro cytocompatibility was evaluated in Hs68 fibroblasts, chondrocytes, and MG-63 osteoblast-like cells. The therapeutic efficacy of TA/HSA NPs was further evaluated in an inflammatory knee arthritis model following intra-articular administration.