Drug Design Development and Therapy
Efficacy and Safety of Clobazam as Adjunctive Therapy for Pediatric Patients with Refractory Epilepsy in Xinjiang, China: A Multicenter Real-World Study
By Ting Zhao, Hong-Jian Li, Hui-Lan Zhang and 4 others.
Abstract
Objective
This real-world retrospective observational study evaluated the efficacy and safety of clobazam as adjunctive therapy in pediatric patients with refractory epilepsy (RE) in Xinjiang to provide evidence for its rational clinical application.
Methods
Treatment efficacy was assessed according to the four-level efficacy criteria established by the First National Epilepsy Academic Conference of the Chinese Medical Association using seizure frequency recorded at the final follow-up. Changes in seizure frequency from baseline were evaluated at 3, 6, and 12 months after treatment initiation. All adverse drug reactions occurring during follow-up were recorded.