European Journal of Prosthodontics and Restorative Dentistry
Vitamin D Deficiency as a Biomarker for Alopecia Areata Severity in Adults: A Systematic Review of Association Measures and Confounding Factors
By Abdulrahman Saleh Alharbi, Abdulaziz Saad Alquhaibi, Reemana Waleed Alsudais and 5 others.
Abstract
Background
Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss. Vitamin D has been suggested as a potential biomarker for disease severity.
Objective
To evaluate the association between vitamin D deficiency and alopecia areata severity in adults through a systematic review.
Methods
A systematic review was conducted according to the PRISMA 2020 guidelines. Electronic databases were searched through March 2026. Four observational studies met the inclusion criteria and were included in the qualitative synthesis. Study quality was assessed using the Newcastle– Ottawa Scale (NOS).