Pharmacy Practice
Incidence of new-onset diabetes and prediabetes among statin users: A Retrospective cohort from hail regions, Saudi Arabia
By Mohsen Huraybi Matar Alshammari, Ali Qureshi, Dr. Baharudin Bin Ibrahim and 1 others.
Abstract
Objective
This study aimed to assess the incidence of NODM and prediabetes among statin users compared with non-statin users in the Hail health cluster, Hail region, Saudi Arabia.
Methods
This retrospective cohort study included 592 adults aged ≥18 years, equally divided into statin-exposed and non-exposed groups (n=296 each). Individuals with prior diabetes or prediabetes were excluded. Data were extracted from medical records, including demographics, BMI, lipid profile, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and details of statin use. NODM was defined as FBG ≥126 mg/dL or HbA1c ≥6.5% at follow-up.
Results
NODM incidence was significantly higher in statin users (9.5% vs. 4.1%, p=0.006); prediabetes occurred more often in the exposed group (6.1% vs. 1.4%, p<0.001), with comparable mean time to the development of new-onset diabetes mellitus (NODM) (30.6 ± 17.2 vs. 26.5 ± 7.7 months; p = 0.29). For risk calculation, cases exposed to statins had 2.33 times higher risk of developing NODM compared to cases not exposed. Additionally, cases exposed to statins had 4.35 times higher risk of developing prediabetes compared to cases not exposed.