European Surgical Research
Dialyzers Outperform Activated Charcoal Filters for Extracorporeal Cisplatin Removal in an Isolated Perfused Porcine Liver Model
By Birte Ohm, Kenji Fukushima, Pascal Paschenda and 7 others.
Abstract
Introduction
Percutaneous isolated hepatic perfusion enables regional delivery of high-dose chemotherapy while limiting systemic exposure through extracorporeal drug removal. In current clinical practice, this is achieved by the use of activated charcoal-based filtration systems, which are limited by finite adsorption capacity and non-selective binding. Hemodialysis filters may provide a membrane-based alternative for extracorporeal drug elimination. This study compared the efficacy of both systems for cisplatin removal.
Methods
An isolated perfused porcine liver model was used. Livers were randomized into charcoal filtration, hemodialysis filtration, or control groups (n=5 per group). Cisplatin was administered into the hepatic circulation, and drug removal was performed according to group allocation. Cisplatin concentrations, liver injury markers, bile production, and blood cell counts were assessed.